|
Acetyl
Hexapeptide-3
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| Acetyl
Hexapeptide-3 is used in formulas as a wrinkle preventative
as well as a wrinkle reducer as an alternative to injections. |
| Acetyl
Hexapeptide-3 is a mimic of the N-terminal end of SNAP-25, one
of three proteins (known as the SNARE complex) that are essential
for neurotransmitter release at the synapsis, which is the chemical
signal for a muscle to contract. |
| As
a wrinkle reducer, studies have shown that Acetyl Hexapeptide-3
at a 10% concentration was able to significantly decrease the
depth of wrinkles after 30 days of treatment. The mechanism
by which Acetyl Hexapeptide-3 is able to accomplish this is
related to the ways in which Acetyl Hexapeptide-3 is able to
assist wrinkle prevention. |
| Acetyl
Hexapeptide-3 performs this activity in two distinct ways: |
| The
first way Acetyl Hexapeptide-3 acts as a wrinkle preventative
is by competing with SNAP-25 for a position in the SNARE complex.
This destabilizes the SNARE complex, preventing the vesicle
from releasing neurotransmitters efficiently, and therefore
attenuating muscle contraction. This causes a reduction in facial
muscle contraction, which is believed to help prevent the long-term
formation of lines and wrinkles. |
| The
second way that Acetyl Hexapeptide-3 acts as a wrinkle preventative
is by reducing the release of catecholamines (the overproduction
of which is known to induce the formation of wrinkles and fine
lines in the skin), specifically adrenaline and noradrenaline.
|
| Acetyl
Hexapeptide-3 is non-toxic and well tolerated by the skin. |
| |
