|
Biopeptide-CL
|
| Like
Palmitoyl Pentapeptide-3, Biopeptide-CL is a synthetic protein
that is a fragment of collagen combined with palmitic acid to
make it more lipophillic, to improve its stability and to enhance
its affinity towards human skin. As with Palmitoyl Pentapeptide-3,
one could look at Biopeptide-CL as a man-made precursor to collagen. |
| Biopeptide-CL
was developed through research to identify a substance that
would behave similarly to retinoic acid but without its drawbacks,
especially in regards to synthesizing collagen. |
| The
reported results are as follows: |
| In
vitro: |
- Increases
collagen production by the fibroblasts by as much
as 350%.
- Increases
hyaluronic acid production by the fibroblasts by as
much as 146%.
|
|
| In
vivo: |
| The
following statistics were gathered using image analysis of volunteers
who used crèmes containing a 3% concentration of Biopeptide-CL
for 28 days. |
| Surface
roughness |
Reduced
17% |
| Mean
depth of wrinkles |
Reduced
23% |
| Depth
of main wrinkle |
Reduced
39% |
| Skin
thickness |
Increased
4% |
|
| The
increase in skin thickness was considered especially notable
and contrasts with the 6% reduction of the skin thickness that
occurs after 10 years of aging. The study concludes to state
that Biopeptide-CL is a potent active cosmetic ingredient without
the adverse effects (including irritation, dehydration or long-term
toxicity and instability) characteristic of retinoids.
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